Pharmacokinetics, urinary excretion and dosage regimen of levofloxacin following a single intramuscular administration in cross bred calves
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چکیده
منابع مشابه
Pharmacokinetics, urinary excretion and dosage regimen of levofloxacin following a single intramuscular administration in cross bred calves
The pharmacokinetics and urinary excretion following single intramuscular administration of levofloxacin at a dose of 4 mg/kg was investigated in seven male cross bred calves. Appreciable plasma concentration of levofloxacin (0.38+/-0.06 microgram/ml) was detected at 1 min after injection and the peak plasma level of 3.07+/-0.08 microgram/ml was observed at 1 h. The drug level above MIC90 in pl...
متن کاملKinetic disposition, urinary excretion and dosage regimen of subcutaneously administered levofloxacin in cross bred calves
The present study was conducted on five healthy male cross bred calves to study the kinetic dispositionand urinary excretion of levofloxacin following its single subcutaneous administration at the dose of4 mg.kg-1. The concentration of levofloxacin in plasma and urine samples was estimated by microbiologicalassay. Peak plasma level of levofloxacin (2.8 ± 0.3 μg.ml-1) was observed at 45 min and ...
متن کاملkinetic disposition, urinary excretion and dosage regimen of subcutaneously administered levofloxacin in cross bred calves
the present study was conducted on five healthy male cross bred calves to study the kinetic dispositionand urinary excretion of levofloxacin following its single subcutaneous administration at the dose of4 mg.kg-1. the concentration of levofloxacin in plasma and urine samples was estimated by microbiologicalassay. peak plasma level of levofloxacin (2.8 ± 0.3 μg.ml-1) was observed at 45 min and ...
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The pharmacokinetics of levofloxacin following its single intramuscular administration (3 mg/kg) was investigated in six male buffalo calves. Peak plasma level of 2.95 ± 0.13μg/ml was observed at 1 h and the drug level above MIC90 in plasma was detected up to 12 h of administration. The bioavailability was 68.1 ± 5.4% and levofloxacin was bound to the plasma proteins to the extent of 19.1 ± 1....
متن کاملPharmacokinetics and Dosage Regimen of Cefepime Following Single Dose Intravenous Administration in Calves
Pharmacokinetics of cefepime was studied after single dose intravenous administration at the dose rate of 5 mg/kg body weight in calves. Blood samples were collected from the jugular vein at predetermined time intervals before and after drug administration. Serum was harvested and analysed for cefepime concentration by reverse-phase high performance liquid chromatography. Following intravenous...
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ژورنال
عنوان ژورنال: Journal of Veterinary Science
سال: 2006
ISSN: 1229-845X
DOI: 10.4142/jvs.2006.7.4.333